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Mechanism 2: Improved insulin sensitivity restoring ovulatory function
This work not only highlights the potential off-target effect of semaglutide as an effective drug to treat metabolic osteoarthritis but also reveals a weight loss-independent repair mechanism that targets metabolic pathways and mediators essential to cartilage repair under osteoarthritis conditions, the study authors wrote
This cardiovascular benefit reflects weight loss, improved glucose control, and direct effects on vascular function
Blood 88(10):3987-97, 1996
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